You are unique – and so is your response to drugs

Your genes tell a unique story about you – including how your body processes different types of pain medications and drugs. This is known as pharmacogenetics.

The Challenge: If pain is such a common experience, why is it so hard to manage?

While all of us have experienced various types and levels of pain, there is no “magic bullet” that works for everyone when it comes to achieving pain relief. What works for one person may not work for another. Part of it comes down to how your body processes and breaks down the components contained in any given drug.

PGX 101

Pharmacogenetics 101

As the name suggests, pharmacogenetics combines two disciplines:

Pharmacology (study of drugs)
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Genetics (study of individual, inherited traits)

Together, pharmacogenetics focuses on a person’s genetic variations and how those variations affect their response to drugs.

How do gene variations affect the way drugs work in my body?

When a drug is taken, the body contains proteins called enzymes that help break down the drug and activate it so it can work in the body. Depending on what genetic variations a person has inherited, enzyme activity will also differ: for example, some people may inherit enzymes that are slower to break down drugs. This could mean a standard dose of drug remains in their body for a longer time, potentially leading to adverse effects. This is why knowing what genetic variations you have can be important: it can help healthcare professionals more accurately predict which drug and at what dose are best for their individual patient.

The Benefits of Pharmacogenetic Testing

Improved patient safety: Severe drug reactions cause hundreds of thousands of hospitalizations each year. Pharmacogenetics may help prevent some of these hospitalizations by identifying patients who are at risk of severe drug reactions.

Improved healthcare costs and efficiency: Instead of a “trial and error” approach, pharmacogenetics can help healthcare professionals and their patients find the most appropriate drugs and doses faster.

What are Single Nucleotide Polymorphisms (SNPs)?

A “snip” can tell a lot.

When we talk about how genetic variations influence the way a body processes drugs it’s critical to talk about SNPs.

“SNPs” (or “snips”), stands for single nucleotide polymorphisms. SNPs are single-nucleotide substitutions of one base for another. Each SNP location in the genome can have up to four versions: one for each nucleotide, A, C, G, and T. Any change in the order of these letters can affect an entire gene, which in turn affects metabolism.

There are millions of SNPs in the human genome. For researchers who work in the field of pharmacogenetics, the idea is to find a connection between SNPs and a response to medication. SNPs can, therefore, be used as a predictive marker of whether a person may react well or poorly to a given medication BEFORE the medication is even taken. This could potentially save patients and healthcare professionals time and money, by eliminating the “trial and error” approach to choosing an appropriate treatment.

Personal Insights in Your Report

Inagene Personalized Insights™ Report

Which pain medications will work best for me?

More details can be found in Sections 2 and 3 of this report but the results of your lab test regarding your personal drug compatibility profile suggests that your body will process most drugs normally and you can take your treatments as prescribed. However, we have identified that the drugs highlighted in RED should be avoided and drugs highlighted in YELLOW should be taken with caution:

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Codeine

Cyclobenzaprine

Naproxen

Hydromorphone

Meperidine

Methadone

Naltrexone

Tapentadol

What type of cannabis would be best?

If you are either inhaling or ingesting, it is recommended to select high CBD products or CBD-rich strains that contain the low levels of THC (less than 5%). This should minimize increased pain sensations and reduce your increased risk of developing paranoia with products containing high THC. More details on the genes tested and your specific results are found in Section 3.

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High CBD

What is my relative risk of dependency?

Your genetic profile shows the presence of only one of the genetic variants with a strong association with a predilection for addition. Considering this factor alone, your relative genetic risk for development of addiction would be considered average. Please remember that one’s risk for addiction is based on more factors than genetics alone. Further details are provided in Section 3 of this report.

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Normal Risk

Frequently Asked Questions

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