Meet "Richard"

“Richard” is one of the six million Canadians with a story to tell about living with chronic pain and the impact on his mental health.  A workplace accident 14 years ago led to a long and difficult journey that has completely  altered his life since.  But thanks to his participation in a recent pilot study involving pharmacogenetic testing, his journey has taken a promising turn.

Richard is a husband and father who has lived with chronic pain for over 14 years, resulting from a workplace accident where he fell over 40 feet on a construction site in 2007. Severe injuries to his left and right shoulders required several surgeries to repair. He is also tormented by painful diabetic neuropathy of his hands and feet. Daily pain has severely impaired his ability to sleep, concentrate, or work, forcing him to go on long term disability, and to retreat from activities and social events he used to enjoy.  As often the case for those living with unrelenting pain, he also developed clinical depression and anxiety.

Richards doctors have prescribed a myriad of medications for his pain and mental health issues over the years that either seemed to provide little to no effect, and/or resulted in side effects ranging from feeling even worse physically, to terrible nightmares and even suicidal ideation.  His persistent symptoms, coupled with the side effects, have had a profound impact on Richard’s quality of life, in addition to his ability to work.

After cycling through multiple drugs and doses for over 14 years, Richard was still struggling with persistent symptoms when his doctor suggested that he participate in a new pilot study investigating whether a new innovative DNA test (Inagene Personalized Insights™ pharmacogenetic test) could help those with chronic pain find more effective treatment sooner.  His physician explained that the study involved taking a one-time cheek swab test, and that a few days later the test results would reveal which drugs and doses would work best with the lowest likelihood of side effects, based on Richard’s genetic profile. Richard decided to participate and take the test in the hopes that it might help him find treatment success, or that it might give him some explanation for why nothing seemed to work well for him without side effects.

The results of the test explained a lot. The test report revealed that at least twelve of the drugs Richard had previously trialled and later discontinued were incompatible with his genetic profile. Looking back, Richard recalled that all of these drugs had either provided little effect and/or were intolerable, resulting in them eventually being discontinued weeks or months later. He and his doctor agreed that, had the test results been available years ago (before starting treatment), many of these medications would likely have been avoided altogether, potentially saving thousands of dollars in wasted drug costs, and (more importantly) many years cycling through drugs that were genetically destined to fail.

At the time of testing, Richard was still taking one medication that the test flagged as a ”Use With Caution” drug for him, based on an increased likelihood of side effects. Not surprisingly, Richard’s doctor had been unable to increase this drug to a dose that provided relief without it becoming intolerable. They decided to replace the drug with another that was more compatible with Richard’s DNA. One month into taking the new medication at the low starting dose recommended by the Inagene report, Richard returned to his doctor to report that his neuropathic pain was almost completely resolved, and that he felt a significant reduction in his shoulder pain. He wasn’t experiencing any side effects with his new treatment, and based on his improved symptoms, his doctor was even able to decrease his overall dose of opioids.

Richard was extremely grateful for having decided to participate in the study and take the test: “I cannot put into words how valuable this is to me. To wake up in the morning and my hands and feet aren’t on fire or screaming at me, to look forward to working again, to be able to do stuff with my kids....I would pay all the money I have for this chance at life again.”

Read more about the pilot study here.